He replaced Len Cariou in Applause, playing opposite Lauren Bacall and later Anne Baxter and Arlene Dahl.

[1] He worked on such 1960s and 1970s soap operas as As the World Turns (Ralph Mitchell, 1977–1979, 1988–1994), The Edge of Night (Rick Oliver, 1966), The Secret Storm (Nick Kane, 1968–1970), Love of Life (Dr. Ted Chandler 1974–1975), Search for Tomorrow, and Where the Heart Is (Robert Jardin, 1972).

[3] His television work also included guest appearances on such nighttime shows as Law & Order, Bob Newhart, Mary Tyler Moore, Cannon, Remington Steele, Kate and Allie, and Dallas.

Charles appeared in films such as Key Exchange, Colorforms, The Royal Tenenbaums, Longtime Companion and Drop Dead Fred.

[4] Demetria Fulton previewed Keith Charles' appearance in Barnaby Jones, playing a character named Marshall Eaton; episode titled "Requiem for a Son"(01/28/1973).