[1] Krach co-founded Ariba, and was chairman and CEO,[2] and is recognized for his work in B2B Commerce and Digital Transaction Management.

[4] On June 20, 2019, he was confirmed by the Senate to become Under Secretary of State for Economic Growth, Energy, and the Environment in the Trump administration.

[8] During his sophomore year (1977), Krach received one of two General Motors scholarships awarded to Purdue engineering students.

The scholarship paid for tuition, books, a living stipend, summer jobs with the automaker, and a full-time position with the company in Detroit following graduation.

[9] After graduating from Purdue in 1979, Krach received a fellowship which also included half salary from General Motors to study for an M.B.A. from Harvard University Business School.

[12] In 1988 Krach became a member of the founding team of Rasna Corporation, a mechanical engineering design software company that was sold to PTC for $500 million in 1995.

[14] From 1996 to 2003, Krach served as co-founder, chairman, and CEO of business-to-business e-commerce company Ariba,[15] creating the world’s largest business network transacting $3.75 trillion in commerce annually.

[17][18] In 2009, Krach became the chairman and in 2011 the CEO of DocuSign, a technology company which provides electronic signature and digital transaction management services.

[19] As CEO, Krach led the creation of the digital transaction management category and the building of the DocuSign Global Trust Network which comprises more than 320,000 companies and 400 million users in 188 countries.

The organization connects young people with industry leaders through a video-based platform piloted in 2018 with retired four-star General Stanley McChrystal, former NASA Administrator Dan Goldin, City Year Founder Michael Brown, and former Deutsche Bank COO Kim Hammonds.

Krach serves as Advisory Board Chairman for New Story, which, among other causes, provided disaster relief initiative for Haiti after Hurricane Matthew in 2016.

[51] Krach gave a $1 million gift to City Year for the organization's San Jose and Silicon Valley branch to reach about 1,000 students at 12 elementary and middle schools through after-school programs focused on teaching science, technology, engineering, and math.

[57][58] He has written about global economic security issues in the Wall Street Journal, Newsweek, The Hill, Washington Examiner, Jamaica Observer, The Daily Telegraph (UK), OGlobo (Brazil), and other publications.

[63] In the spring and summer of 2020, Krach and his State Department team supported efforts to repatriate more than 60,000 Americans who were stranded overseas by the coronavirus pandemic, and also worked to accelerate supply chains for PPE and other vital supplies to safeguard the lives of healthcare workers, patients, and American families.

Bloomberg retracted the article and published a letter to the editor from Krach titled "Public Service Is Worth More Than a Billion."

In his letter, Krach pointed out that "I divested my entire stake in DocuSign and my other holdings as a condition of joining the federal government, meaning I profited in no way.

"[64] He claimed the misstatement jeopardized the mission and credibility of his worldwide team as they were responded to the myriad issues spawned by the pandemic and had the potential to undermine the work of thousands of civil servants and foreign service officers by undercutting their ability to operate with the trust necessary to accomplish the mission.

[71] The US simultaneously announced a $7 billion arms deal with Taiwan, including sea mines, drones and air-to-surface missiles.

"[74] Undersecretary of State Krach was responsible for the development and implementation of the Clean Network Alliance of Democracies which is designed to be a US government-led global effort  to address what the State Department describes as "the long-term threat to data privacy, security, human rights and principled collaboration posed to the free world from authoritarian malign actors.

[77][78] Krach secured commitments to the Clean Network from other EU countries, such as Estonia, Albania, Austria, Germany, Luxembourg, Belgium, Spain, Portugal, Bulgaria, Kosovo, North Macedonia, and Cyprus.

[83] The alliance also includes other countries such as Japan, Israel, Australia, Singapore, Taiwan, Canada, Vietnam, India, and companies like Oracle, HP, Reliance Jio, NEC, Fujitsu, Cisco, Siemens, Softbank, and VMware.

[87] Krach led the State Department's efforts to protect American investors from unknowingly financing what he described as the People's Republic of China's military, security, intelligence apparatus and, human rights abuses.

Bloomberg noted, "As far back as August, a senior State Department official, Keith Krach, wrote a letter warning universities to divest from Chinese firms ahead of possible delistings.

"[92] On January 14, 2021, Krach cautioned financial institutions by holding a press conference and issuing a U.S. Department of State fact sheet titled "Communist Chinese Military Companies Listed Under E.O.

In July 2024, Krach accepted the position of Chairman of the Board of Directors for the US-Taiwan Business Council (USTBC),[97] succeeding Michael R. Splinter.

The delegation, comprising senior executives from prominent American and Taiwanese companies, expressed support for Taiwan’s vibrant democracy and explored opportunities for collaboration in key industries.