The school educates students in the majority of the city of Keller, western Southlake, northwestern Colleyville, northern North Richland Hills, and most of Westlake, including the Vaquero development.

Keller, Central, Fossil Ridge, and Timber Creek all share the same stadium and natatorium.

The program, which consists of participants from all 4 KISD high schools, has won numerous awards and recognition.

Keller High School has won numerous University Interscholastic League (UIL) State Championships in the following sports: In 2017, Keller Boys' Varsity Basketball Team went to the state championship in San Antonio, Texas but lost to Karen Wagner High School in the semifinals at the Alamodome with a crowd of more than 12,000 spectators at the game.

Keller High Boys Swimming & Diving has won 2 State Championships in the 6A Class of Texas UIL.

The Boys Swimming & Diving additionally broke 4 National Records in the 2024 state championship.

The Boys Swimming & Diving has also produced 10 NCAA Division I recruits since 2014 with 6 coming from the last 2 years, 2 of which (Maximus Williamson & Cooper Lucas) finished at 1st in there class worldwide with a perfect 1.00 power index.

[4] In 2018, the Keller High School Marching Band represented the entire state of Texas at the annual Macy's Thanksgiving Day Parade in New York City.

An opposition position garnered 3000 signatures, with a trustee comparing the students' aims to Nazi actions in the Holocaust.