[3] Keiderling's father was in the U.S. Foreign Service and had met her Bolivian mother on his first international assignment in Cochabamba, Bolivia.

Her U.S. assignments included ones as senior Panama desk officer, public diplomacy desk officer for the Caribbean, acting deputy director for Central American Affairs, strategic language issues coordinator in the Bureau of Human Resources, chief of staff in the Iraq Office, and principal deputy assistant secretary for the Bureau of Educational and Cultural Affairs.

She was tapped by President Obama to become United States Ambassador to Uruguay in 2016 and was confirmed by the Senate later that year, on May 17.

[8] From 2019 to 2021, Keiderling served as Deputy Commandant and International Affairs Advisor at the US National War College.

In addition to English, she speaks Spanish, Portuguese, French and Russian, as well as some Italian and Romanian.