It stars Jesse Spencer, Taylor Kinney, Monica Raymund, Lauren German, Charlie Barnett, David Eigenberg, Teri Reeves, Eamonn Walker, Yuri Sardarov, Christian Stolte, Joe Miñoso, Kara Killmer, Dora Madison Burge, Steven R. McQueen, Miranda Rae Mayo, Annie Ilonzeh, Alberto Rosende, Daniel Kyri, Adriyan Rae, Hanako Greensmith, Jake Lockett, Jocelyn Hudon and Dermot Mulroney,[1] it premiered on October 10, 2012.

[54] Producer John L. Roman was involved from the beginning having worked with the Chicago Fire Department and Deputy District Chief Steve "Chik" Chikerotis on Backdraft.

I told them I'd do it under one condition: the TV show is making an investment to the Firefighters' Widows and Orphans Fund.

[57] The Chicago Fire sports team accepted the shared name and showed the series premiere on October 2, 2012, at Toyota Park after a game with the Philadelphia Union.

[59] After receiving an additional script order in October, Chicago Fire was picked up for a full season on November 8, 2012.

[4][5] For the first five seasons Matt Olmstead, Michael Brandt, and Derek Haas served as the series showrunners.

[75] Executive producer Andrea Newman was promoted to co-showrunner with Haas for the tenth and eleventh seasons.

Chicago artist and retired firefighter Lee J. Kowalski's oil paintings of fire scenes can be spotted in several episodes.

Molly's, a small bar owned by Herrmann, Dawson and Mouch, was filmed at Lotties in Bucktown.

[80] In November 2012, WGN-TV reported a plane crash at 29th and Martin Luther King Drive on their morning newscast and showed live footage for a few minutes before realizing it was merely a set piece staged for Chicago Fire and not an actual emergency situation.

The main cast includes Jason Beghe, Jon Seda, Sophia Bush, Jesse Lee Soffer, Patrick Flueger, Elias Koteas, Marina Squerciati, LaRoyce Hawkins and Archie Kao.

In February 2015, NBC announced plans to make another spin-off, the medical drama Chicago Med.

[120] On May 1, 2015, Chicago Med was officially ordered to a series,[121] starring Oliver Platt, S. Epatha Merkerson, Nick Gehlfuss, Yaya DaCosta, Torrey DeVitto, Rachel DiPillo, Marlyne Barrett, Colin Donnell and Brian Tee.

aired a backdoor pilot of the short-lived legal drama series Chicago Justice, which ran from March 1, to May 14, 2017.