In February 2018, she was named the Big Ten women's basketball player of the year by the conference's coaches.

Mitchell participated in the 2024 Skills Challenge at 2024 WNBA All-Star Weekend after Fever teammate, Erica Wheeler, was unable to attend due to the global computer outages delaying her travel.

[6] She would earn back-to-back WNBA All-Star appearances in 2023 and 2024, alongside Fever teammates Aliyah Boston and Caitlin Clark.

After entering free agency in 2025, the Fever designated Mitchell as a core player, giving the team exclusive rights and guaranteeing her a supermax contract for the 2025 season.

[11] Mitchell signed with the Shanxi Flame of the Women's Chinese Basketball Association for the 2024–2025 season.