In February 2018, Isaacs was nominated by President Donald Trump to be the US candidate to run for Director General of the United Nations International Organization for Migration (IOM).
[3] Isaacs would later assist in and organize relief efforts in a variety of locations, including Rwanda (during the Rwandan genocide in 1994),[4] Somalia, El Salvador, Bosnia, Sudan, and Afghanistan.
[2] In 2014, Isaacs testified before a House Foreign Affairs subcommittee, criticizing the government's response to and effort to combat the spread of Ebola in Guinea, Liberia, and Sierra Leone.
[9] At the time of Isaacs's nomination for the directorship at IOM, he was in Bangladesh, providing diphtheria treatments to Rohingya refugees as part of his work for Samaritan's Purse.
His Twitter account was soon made private, and he issued a statement saying, "I deeply regret that my comments on social media have caused hurt and have undermined my professional record.