As a terminus station is located within the locality, several feeder routes run throughout the various neighborhoods, including Casablanca, la Ciudadela, El Recreo, la Biblioteca El Tintal, Patio Bonito, Corabastos, and Castilla.

Ciudad Kennedy formed part of the land settled by Muisca probably as far back as the 6th century BC, and its historic name in Muysccubun is Techotyna.

In 1961, an urbanization project was undertaken, financed in part by the Alianza para el Progreso (Alliance for Progress).

The locality was known as Ciudad Techo until 1963, when the name was changed in honor of the assassinated John F. Kennedy, who visited Bogotá in 1961 and supported the Alliance for Progress.

The western and southern parts of the locality are developed as commercial and industrial zones, including the Bavaria brewery.