He played college football at Vanderbilt, and was signed as an undrafted free agent by the Buffalo Bills in 2014.

In 2012, he started all 13 games, while leading the team with 90 tackles, three pass deflections, two interceptions and a forced fumble.

In 2013, he earned first-team All-SEC honors after he recorded a team leading 91 tackles, with nine pass deflections and five interceptions.

[5] He also led the SEC and shared the NCAA lead while setting a team record with five forced fumbles.

[7] On September 1, 2018, he was waived for final roster cuts before the start of the season, but signed with their practice squad the following day.

[13] Ladler was waived/injured during final roster cuts on August 31, 2019,[14] and reverted to the team's injured reserve list the next day.

[18] After the CFL canceled the 2020 season due to the COVID-19 pandemic, Ladler chose to opt-out of his contract with the Lions on August 31, 2020.