Founded by the Vincentian order, it was the first Catholic seminary in American territory west of the Mississippi River.

[3] In 1858, the major and minor seminaries both moved to Cape Giradeau, Missouri, to become Saint Vincent College.

The original high school program in Shrewsbury was now called Saint Louis Preparatory Seminary South.

This left Kenrick School of Theology and Cardinal Glennon College, both now operating under the name of Kenrick–Glennon Seminary.

[3] In November 2016, the Archdiocese of St. Louis settled a lawsuit involving the sexual abuse of a minor at a summer camp run by Kenrick–Glennon Seminary.

[5] In 2021, Kenrick-Glennon committed to following a set of five sexual misconduct policy benchmarks for seminaries that was created by a working group at the University of Notre Dame.