He visited Egypt for the first time in 1963 and was active in digs in Nubia associated with relocation work necessitated by the building of the Aswan Dam and the flooding of the Nile Valley to create Lake Nasser.
Weeks' professional career began with his appointment as Professor of Anthropology at American University in Cairo for the academic year 1971–72.
His wife, Susan Weeks, was also an archaeologist and a gifted artist before her death in December 2009.
As part of this project, Weeks introduced hot air ballooning to the Luxor area with the intent of making inexpensive aerial surveys, which grew into an important part of the local tourist industry.
However, a more important achievement of the Project was its 1995 discovery of the identity, and vast dimensions, of KV5, the tomb of the sons of Ramesses II in the Valley of the Kings.