[1][2] He is best known for starring in manga adaptations, including the films L DK (2014), Orange (2015), Your Lie in April (2016), JoJo's Bizarre Adventure: Diamond Is Unbreakable Chapter I (2017), Psychic Kusuo: The Disastrous Life of Saiki K. (2017), Kingdom (2019), and television series Death Note (2015) and Alice in Borderland (2020–present).

[4] Yamazaki was scouted during his third year of junior high school by his agency, Stardust Promotion, on Takeshita Street, Harajuku while on his way home from a soccer match.

[1][2] Yamazaki made his acting debut in 2010 when he was cast in the TV series Atami no Sousakan as a mysterious high school student.

In 2014, Yamazaki made a breakthrough in his career starring in the live-action film adaptation of the highly successful manga L DK, alongside Ayame Goriki.

That same year, he acted in three drama series, including Baseball Brainiacs, where he was cast alongside actors Sota Fukushi and Yuto Nakajima.

[citation needed] That same year, he appeared in the television adaptation of the popular manga series Death Note as L, and the NHK Asadora Mare, led by Tsuchiya Tao.

He played the lead role of Kosei Arima, a gifted pianist, alongside Suzu Hirose, who portrayed Kaori Miyazono.

That same year, Yamazaki was chosen to star in a special short film to celebrate the 10th anniversary of Yasuhisa Hara's historical manga Kingdom[17] as the main character, Xin.

[19] The film received positive ratings from critics, which mostly praised Yamazaki for successfully portraying the cheerful and friendly Yuki Hase.

[citation needed] He would then continue to appear in other live-action films throughout the year, including JoJo's Bizarre Adventure: Diamond Is Unbreakable Chapter I, Psychic Kusuo: The Disastrous Life of Saiki K., and Hyouka: Forbidden Secrets.

[20] In January 2018, Yamazaki secured his first leading role in a television series, playing Ōtarō Dōjima, a top nightclub host, in the NTV winter drama Kiss that Kills, [21] alongside Mugi Kadowaki, Mackenyu and Masaki Suda.

[38] Yamazaki's close friends in the entertainment industry include fellow actor Masaki Suda, whom he worked with in Kiss That Kills (2018),[39] and South Korean singer Jeonghan.