Kentucky's 22nd Senatorial district is one of 38 districts in the Kentucky Senate.

Located in the central part of the state, it comprises the counties of Garrard, Jessamine, and part of Fayette.

It has been represented by Donald Douglas (R–Nicholasville) since 2021.

[2] From 1930 to 1931, the district was represented by Happy Chandler, who would later be elected governor and U.S. senator from Kentucky.

On January 1, 2025, the district had 99,419 registered voters, who were registered with the following parties.