The road turns to the north and winds through forested areas with occasional residential development.

The road heads northwest and intersects the southern terminus of KY 1107 before it crosses Levisa Fork and a CSX railroad line.

The route curves north and gains a second northbound lane as it passes through wooded areas of development.

The road runs through more forested areas and curves to the north, where it gains a second northbound lane.

The route curves to the west and narrows to two lanes, intersecting the southern terminus of KY 321 Bus.

KY 321 continues north as a four-lane divided highway through wooded areas with some development and comes to its northern terminus at US 23.

An older KY 321 existed in Bowling Green; this route was given to the city on February 9, 1983.