Kentucky Route 550 (KY 550) is a 43.212 miles (69.543 km) state highway in eastern Kentucky that runs from Kentucky Routes 15 and 80 in northwestern Hazard to Kentucky Route 80 and Judge Road in Eastern via Darfork, Dwarf, Fisty, Carrie, Hindman, Garner, Mousie, Lackey, Garrett, and Eastern.

It runs concurrently with KY 476 for most of its course through eastern Perry County.

At Dwarf, KY 550 separates and moves into Knott County.

It then has a runs concurrently with KY 7 after it enters Floyd County.

KY 550 continues into southern Floyd County until reaching its eastern terminus at a third intersection with KY 80 at the town of Eastern.