The Panthers compete in the NCAA Division II as a member of the Great Midwest Athletic Conference (G-MAC), They have won the NCAA Division II tournament eight times, most recently in the year 2001.

[2] Joel Utley was the "Voice of the Panthers" from 1962 to 2022[3] (including all eight championships), broadcasting a play-by-play of all Wesleyan basketball games on local Owensboro radio station WBIO.

[4] KWC will leave the Great Lakes Valley Conference (GLVC) after the 2012–13 academic season.

[5] The Panthers advanced to the Division II championship game six consecutive years (1998–2003), winning in 1999 and 2001; the team later forfeited its 2003 runner-up status after it was revealed they had let two ineligible transfer players play.

Dazmond Starke 2012–2013, led the NCAA Division II in Field goal % with 67.4%.