Keokee is an unincorporated community and census-designated place (CDP) in Lee County, Virginia, United States.

[7] The CDP includes the neighboring unincorporated communities of Darnell Town and Rawhide.

Keokee is 15 miles (24 km) by road northeast of Pennington Gap, the largest town in Lee County, and 13 miles (21 km) west of Big Stone Gap.

28.1% of all households were made up of individuals, and 14.1% had someone living alone who was 65 years of age or older.

About 19.4% of families and 20.9% of the population were below the poverty line, including 27.1% of those under the age of 18 and none of those 65 and older.