Keoni Ana, full name John Kalaipaihala Young II (March 12, 1810 – July 18, 1857), was a politician in the Kingdom of Hawaii, serving as Kuhina Nui of the Hawaiian Islands and Minister of Interior.

The two friends' relationship was severely damaged when Keoni Ana was caught in the bedroom of Queen Kalama, the King's wife, shortly after the birth of Prince Keaweaweulaokalani in 1839.

Keoni Ana held several government positions, including service in the House of Nobles 1841–1856, the Privy Council 1845–1857,[5] as a Supreme Court justice, royal governor of Maui, and as chamberlain of Kamehameha III's household.

[6] On June 10, 1845, he was appointed Kuhina Nui by Kamehameha III[citation needed] because Victoria Kamāmalu, the designated successor of her mother, Kīnaʻu, was still a minor.

After Keoni Ana became Kuhina Nui the Legislative Assembly passed several acts that organized the executive ministries and departments of the government.

As a very close friend and ally of the Kauikeaouli, Keoni Ana recognized that the Kuhina Nui's authority challenged the king's prestige and power.