It was established by the Kerala University of Health Sciences Act 2010, for ensuring proper and systematic instruction, teaching, training, and research and also to have uniformity in the various academic programmes in medical and allied subjects in the State of Kerala.

The University is mandated to affiliate all Colleges and Institutions in Kerala, imparting professional education in health care.

[1] KUHS was established in 2010 through an ordinance and later Kerala University of Health Sciences Act, 2010.

Autonomous colleges can frame their own schemes of study, curricula and evaluation, without need of the approval of the university.

These colleges also have the freedom to conduct add on courses and supplementary semesters for students who may be in need of it.