[2] Diagnosis of infectious keratitis is usually made clinically based on the signs and symptoms as well as eye examination, but corneal scrapings may be obtained and evaluated using microbiological culture or other testing to identify the causative pathogen.

[3] Herpes keratitis is classically associated with a branching (dendritic) infiltrate pattern of inflammation in the corneal epithelium and may cause clouding of the cornea.

[3] Approximately 8-20% of cases of shingles (due to VZV reactivation) involve the eyes as herpes zoster ophthalmicus.

[3] Infectious keratitis sometimes presents as corneal edema, or with a hypopyon (a collection of inflammatory cells in the anterior chamber of the eye).

Infectious keratitis can progress rapidly, and generally requires urgent antibacterial, antifungal, or antiviral therapy to eliminate the pathogen.

There was no rebound effect, or increased rate of HSV related eye disease upon stopping acyclovir prophylaxis.