She is known for her roles as Donna Clark in the AMC period drama series Halt and Catch Fire (2014–2017) and Lucy Bennett, the lead/narrator in the final season of the ABC medical sitcom Scrubs (2009–2010).

[1] She graduated from Montclair Kimberley Academy,[2] where her father, Kenneth Bishé, taught social studies,[3] and then enrolled at Northwestern University in 2006.

[7] Bishé made her screen debut in 2007 when she portrayed Sarah Rosen in The Half Life of Mason Lake, a low-budget production.

After appearances as an extra in the first film adaptation of Sex and the City and The Lucky Ones, and a small role in The Understudy (2008), Bishé was cast in Night Life, a television pilot directed by Scrubs star Zach Braff.

In December 2009, Bishé took on the lead role on the ABC medical sitcom Scrubs, that of Lucy Bennett, the show's new narrator, taking over from Zach Braff.