As per Federal Aviation Administration records, the airport had 148,645 passenger boardings (enplanements) in calendar year 2023,[4] which was a 3.38% increase from 2022.

Aircraft operated into the Annette Island Airport (ANN) for flights in the local southeast Alaska area included the Grumman Goose and Consolidated PBY Catalina with these amphibian aircraft being utilized to link the airport with the Ketchikan Harbor Seaplane Base.

[7] In addition, Annette Island was served with Boeing 720 jetliners operated by Pacific Northern and successor Western Airlines later during the 1960s.

[12] Alaska Airlines has flown from the airport for over 40 years and also operated Grumman Goose and Super Catalina amphibian aircraft into the seaplane base serving Ketchikan prior to the opening of the airfield in 1973.

[14] Ketchikan International Airport covers an area of 2,600 acres (1,052 ha) at an elevation of 92 feet (27 m) above mean sea level.

[15] For the 12-month period ending January 31, 2019, the airport had 15,959 aircraft operations, an average of 44 per day: 61% air taxi, 33% scheduled commercial, 4% general aviation, and <1% military.

[22] Alaska Airlines operates Boeing 737-700 jet freighters into the airport as well with service to Anchorage, Juneau, Seattle and Sitka.