[2] Lisch played college basketball for the Saint Louis Billikens between 2005 and 2009, where he finished as the sixth-highest scorer in school history.

At Saint Louis, Lisch played under coaches Brad Soderberg (2005–07) and Rick Majerus (2007–09) while earning a bachelor's degree in marketing and an MBA in four years.

[3] As a freshman playing for the Billikens in 2005–06, Lisch was selected to the A-10 All-Rookie Team and was a three-time recipient of the A-10 Rookie of the Week award.

He was the team's second-leading scorer at 11.1 points per game and top three-point shooter with 58 treys, which set the SLU freshman single-season record.

[6] As a result of his standout four-year tenure, Lisch was named to the Billikens' All-Century Team and was inducted into the SLU Hall of Fame.

[9] He struggled at the start of the 2009–10 season,[10] and due to the high-profile imports traditionally signed by the Wildcats, some were calling for Lisch to be cut as early as the preseason tournament.

[11] Lisch debuted with a 12-point effort on September 25, 2009, against the Wollongong Hawks,[12] and then had the game-winning, buzzer-beating 3-pointer the following game against the Townsville Crocodiles on October 2 to finish with 16 points.

[12] The Wildcats finished the regular season as minor premiers with a 17–11 record, and faced the Gold Coast Blaze in the semi-finals.

[12] With the series tied at 1–1, Lisch took over in Game 3 to score a game-high and season-high[12] 29 points with five 3-pointers in leading the Wildcats to the championship with a 96–72 victory over the Hawks.

[19] The Wildcats finished the regular season in fourth place with a 16–12 record, and faced the first-placed New Zealand Breakers in the semi-finals.

[25] He helped the Wildcats defeat the Gold Coast Blaze 2–1 in the semi-finals to move on to the 2012 NBL Grand Final series.

[39] Following the conclusion of the 2012–13 NBL season, Lisch joined Piratas de Quebradillas of the Baloncesto Superior Nacional (BSN) alongside former Wildcats teammate Shawn Redhage.

[40] He went on to lead the team to their first championship in over 30 years, beating Ponce Lions in six games in the best-of-seven BSN finals series.

[52][53] In his debut for the Hawks on October 8, 2015, Lisch contributed seven points before hobbling off the court during the third quarter of their game against the Cairns Taipans with a knee injury.

[61] Lisch helped the Hawks finish the regular season in third place with a 17–11 record, which set them up to play the second-seeded Perth Wildcats in the semi-finals.

Their chances of defeating the Wildcats were weakened when Lisch went down heavily on his left ankle late in the first quarter of Game 1 in Perth and did not return, only coming back to the team's bench in the second half in a moon boot on crutches.

He recovered in time to face the Wildcats in Game 3;[65] however, despite Lisch's return, the Hawks were defeated 89–74, as they bowed out of the finals with a 2–1 series loss.

[66] Prior to the start of the finals, Lisch was named the recipient of the Andrew Gaze Trophy as the NBL's most valuable player for the 2015–16 season.

[69] He also became the fourth Hawks player to win the award, joining Mike Jones (1981), Gary Ervin (2011) and Rotnei Clarke (2014), while becoming only the sixth player in NBL history to have been named MVP in multiple seasons, joining Andrew Gaze (7), Scott Fisher (2), Leroy Loggins (2), Robert Rose (2) and Chris Anstey (2).

On April 2, 2016, after turning down a contract extension with the Illawarra Hawks,[75] Lisch signed a three-year deal with the Sydney Kings.

Lisch underwent minor knee surgery during the off-season to help resolve a nagging injury that curtailed his performance in 2016–17.

[95] In his return game on January 13, Lisch recorded seven points and four rebounds in 15 minutes off the bench before fouling out of the Kings' 104–101 loss to the Adelaide 36ers.

[102] After colliding with a teammate and sustaining an elbow to his jaw at training on November 17, Lisch missed the Kings' game the following day.

[103] Lisch helped the Kings finish the regular season in third place with an 18–10 record, before going on to lose 2–0 to Melbourne United in the semi-finals.

[104] He had opportunities to join the South East Melbourne Phoenix and the Illawarra Hawks during the off-season but decided to take a pay cut and re-commit to the Kings.

[111] He played the final three games of the regular season to help the Kings win the minor premiership with a first-place finish and a 20–8 record.

[115][116][117] In May 2016, Lisch was named in the Australian national team's 17-man squad for a selection camp in Melbourne in July ahead of the Rio Olympics.

[118] He was subsequently named in the final 12-man squad, joining former Perth Wildcats teammate Damian Martin as Olympic debutants.

[2][120] Lisch was a key reserve for the Boomers during their Olympic campaign, helping Australia reach the bronze medal game.

The couple met while Rachel was playing for the West Coast Waves in the Women's National Basketball League (WNBL).