Stitt was reelected to a second term in 2022, defeating Superintendent of Public Instruction Joy Hofmeister, a Republican turned Democrat, with 55.4% of the vote.

According to the Oklahoman, a Gateway corporate attorney said there were misrepresentations and insufficient background checks by employees in the Georgia office but Stitt was not involved.

[27] In the general election, Stitt was endorsed by former primary rival Mick Cornett,[28] incumbent governor of Oklahoma Mary Fallin,[29] and President Donald Trump.

A member of the Chickasaw Nation and former Republican state representative, Billy viewed Stitt's negotiation position as one of "unnecessary conflict.

In April 2022, Stitt supported, and signed into law, SB 612, which makes performing an abortion a crime punishable by 10 years in prison or a $100,000 fine, with exceptions for medical emergencies but none for rape or incest.

[54] Oklahoma has a long history with capital punishment, having conducted the second-most executions since the death penalty was reinstated in Gregg v. Georgia (1976).

The Tulsa World reported that the District Attorneys were taking an increasingly more political role that has "to some degree weakened" the board's influence.

[68][69] When the report came out, Stitt's office issued a statement saying, "This is the latest in a string of unfounded hit jobs by the Oklahoma County District Attorney and other political insiders.

"[72] Later, Stitt "asked a judge to strike from a grand jury report a finding that he placed 'improper political pressure' on his appointees to the Oklahoma Pardon and Parole Board."

Beginning with the adoption of State Question 780 by Oklahoma voters in 2016, advocates for criminal justice reform sought additional measures.

[73] In May 2019, Stitt proposed several ideas, including making SQ780's sentencing standards retroactive, prohibiting criminal records from being considered for professional licensing, and restructuring the funding scheme for the various district attorney offices.

Transgender people criticized Stitt's actions, saying it was difficult for trans individuals to navigate life when their official documents do not match their gender identity.

[83] In May 2023, Stitt vetoed funding for Oklahoma's PBS network OETA, accusing it of broadcasting pro-LGBT content that "indoctrinat[es]" children.

"[89] The statement was criticized by former Governor Frank Keating, former attorney general Drew Edmondson, and animal rights groups as an endorsement of the commission's efforts to reduce the penalty for cockfighting in Oklahoma to a misdemeanor.

Under the direction of an oversight committee composed of members of the State Senate and House of Representatives, the office will provide auditing, evaluation, and investigative services for the legislature relating to the governor's proposed budget and expenditures by the executive branch.

[97] Stitt also signed HB2010, which expands the places a firearm may be carried to include municipal zoos and parks, regardless of size, as long as it is concealed.

Under the Act, the State of Oklahoma offers each federally recognized Indian tribe the right to conduct commercial gambling within its territory upon accepting the terms of a uniform state-tribal gaming compact.

In a July 2019 op-ed in the Tulsa World followed by a letter to the chiefs of 35 Oklahoma tribes, Stitt called on tribal leaders to renegotiate the terms of the compact before its expiration date.

[102] Stitt's office maintained the compact is not subject to automatic renewal, a claim the tribes rejected, believing it will continue indefinitely unless changes are mutually agreed upon.

[107] On December 31, Stitt signed an extension to the hunting and fishing license compact with the Choctaw Nation, a previous point of contention.

[108] On July 28, 2020, U.S. District Judge Timothy D. DeGiusti ruled in the tribes' favor, holding that their compacts with the state automatically renewed for an additional 15-year term on January 1, 2020.

The Court ruled that Stitt "exceeded his authorities" in entering into the compacts because they would have allowed gaming that is illegal in Oklahoma, like sports betting.

[117] In July 2020, a video Stitt made had a number of erroneous claims about Native American rights, such as that they do not have to obey the speed limit.

[118] Also, one day after the veto override, Attorney General Gentner Drummond entered a "federal lawsuit on behalf of the state" originally brought by Stitt against the U.S. Department of Interior and four tribal nations.

Drummond claimed Stitt was "betraying his duties to the state and wasting taxpayer money on private law firms" and that the compacts Stitt signed "with the Comanche Nation, the Otoe-Missouria Tribe, the United Keetoowah Band of Cherokee Indians, and the Kialegee Tribal Town are invalid because he signed the compacts without first getting legislative approval for expanded types of gaming listed within them, including sports betting.

[120][121] He later deleted the tweet, and his spokesperson said, "the governor will continue to take his family out to dinner and to the grocery store without living in fear and encourages Oklahomans to do the same.

[127] In April 2020, Stitt ordered a massive purchase of hydroxychloroquine, a drug of unproven efficacy as a treatment against the coronavirus but which had been heavily promoted by Donald Trump and his allies.

[129] Stitt sent U.S. Defense Secretary Lloyd Austin a letter requesting that COVID-19 vaccine requirements for the Oklahoma National Guard be suspended.

[134][135] Days later, Senate Pro Tem Greg Treat was informed he was the acting governor and could declare a state of emergency, which he eventually did.

[151][152] On October 31, 2022, Stitt's 20-year-old son was found intoxicated in a parking lot in Guthrie, Oklahoma, while in possession of firearms, including a gun belonging to his father.