The city of Khairpur Tamewali is the tehsil headquarters which is administratively subdivided into eight union councils.

The main administrative districts are Khairpur Tamewali, Behli, Guddan, Inaiti, Israni, Jhandani, Kotla Qaim Khan and Syed Imam Shah.

There is also a military airbase which is used to train multiple air forces including those of Saudi Arabia, Egypt, United Arab Emirates, China, Oman and Pakistan.

Shrine of famous Sufi saint Peer Syed Ghulam Mohyudin Gillani (Peer Syed Chup Shah Sarkar) is located near Khairpur Tamiwali Police Station, he is one of the descendants of Ghaus Pak Abdul Qadir Gillani and also from the family of Muhammad.

Another ancient 200+ years old Shrine of Syed Badar Shah Gillani is present nearby.