[4] In 1960–61 they formed a combined team with Hyderabad, which competed in the Ayub Trophy as Hyderabad-Khairpur, losing one match and drawing the other.
[6] They won their next match, against Bahawalpur, by two wickets, thanks to outstanding performances by Aizazuddin, who made 31 and 101 (Khairpur's first century), and Abdul Aziz,[7] who took 7 for 66 and 5 for 97.
Their only appearance in 1966–67 was in a combined Hyderabad-Khairpur-Quetta team, which lost its only match to East Pakistan in the Ayub Trophy.
Aged only 12 years and seven months, and batting at number eight, Mohammad Akram[9] made 111 in the first innings on his first-class debut.
Several Khairpur players later played for the neighbouring team of Sukkur when it assumed first-class status in the 1974–75 season.
Mohammad Akram made 464 runs at 27.29, and scored two of Khairpur's four centuries; he later played a few matches for Sukkur during its period as a first-class team between 1974 and 1987.
Tahir Ali played 24 matches for Khairpur, taking 98 wickets at an average of 19.64 with his left-arm spin and making 437 runs at 12.85, a useful contribution in a weak batting side.
During its first-class period it played three matches at the Municipal Stadium in Sukkur, about 30 kilometres to the north, winning all three.