He started acting and directing (English and Arabic language) plays and musicals in Egypt while studying theatre at The American University in Cairo.

Since 2016, he has acted in several English-speaking roles, such as Tyrant on FX, History Channel's Vikings, and the BBC's TV mini-series The Last Post, and announced to appear in the upcoming Netflix Show Messiah 2019.

[4] He is one of the most recognizable celebrity faces of the 2011 Egyptian Revolution, taking part in mass demonstrations in Cairo that led to the removal of President Mubarak.

Khaled was naturally interested in acting at an early age and appeared in a film (Madness of Love) starring Naglaa Fathi.

He played water polo for his varsity team while based in Europe (1986–9), worked part-time as a fashion model (1993–6), and was a late-night talk show host and radio presenter in the late 1990s.

[8] The first phase of Naga's acting career (1989–2002) was largely on stage (in the theatre), although he began hosting TV talk shows in 1998,[9] which contributed to his popularity as a media personality in Egypt and Arabic speaking states.

From 2010 onwards Abol Naga mostly played the lead of much more diverse and complex roles, continued to win numerous awards as an actor and as a producer from regional and international prestigious film festivals.

After "Sleepless Nights" aka: Sahar El Layali, Abol Naga acted in more films in a short period of time.

In 2005–2006 he appeared in several more films: Harb Italia (Italian War), Malek wa Ketaba (Heads and Tails), and the romantic comedy Banat West El Balad (Downtown Girls).

In 2006 he appeared as the lead in Leabet el hob (The Game of Love) – for which he received Best Actor at the Alexandra International Film Festival.

[3] In a review of In the Heliopolis Flat, Mohamed El-Assyouti of Al-Ahram Weekly noted a tendency for Abol Naga "to have been type-cast as the middle-class romantic star co-lead in almost all his films this year".

Originally due for mainstream release in Cairo on January 26, 2011, the film was re-released after the protests in Tahrir Square and won numerous awards and gained a regional and worldwide acclaim.

In 2010 he became involved as filming director of the student play production of The BuSSy monologues – "True stories about young men and women in Egypt".

In September 2013, in a unique stage play reading in Arabic; Cancelled,[17] Khaled Abol Naga seamlessly takes on the lead role of Hassan, the director, and does a perfect and utterly hilarious impersonation of the talented, kind hearted and easily irritated director-professor who loves his students, but constantly criticizes them and the entire generation to which they belong, In this rough form of a play Abol Naga's theatrical capabilities shined.

In 2003 he played a main role among an all star cast as Sherif in Ahlam El Sabaya (translates: The Girl's Dreams) directed by Hosny Ghoneim.

The following year he performed in the romantic comedy radio drama Back to Love (directed by Hessein Ibrahim) (2004) as the lead Tarek.

Naga has used his status as a film star in the Arab region and even before as a TV celebrity to raise awareness for a variety of issues in Egypt and the Middle East.

The play was constructed of hundreds of acts based on real letters of true but taboo stories of young women and men from Egypt.

Abol Naga directed and produced with others a filmed version in 2010 after being invited by the students to watch it in the parking lot of the Cairo Opera house!.

[39] In the wake of the January 1, 2011 Alexandria bombing, Abol Naga visited the victims and survivors in hospitals,[26][27][28][29] and lead candle lit vigils[40][41] denouncing violence against copts and to promote religious tolerance in Egypt.

[27][42] In late January 2011, he participated in the Egyptian Revolution in Tahrir Square, having been a signatory to Mohamed ElBaradei's manifesto for political reform, Together for Change on March 28, 2010, with other film makers and directors.

[46] Outline of his social work: Naga has won a multitude of awards as an actor specially in the years 2004 for Sleepless Nights, and 2014 for Villa 69 and Eyes of a Thief.