Khamis participated in a competition held by McDonald's that offered the chance to take part in the Norway Cup youth tournament.

After attending several try-out sessions in Jounieh, Lebanon, he was selected to join the team traveling to Norway aged 10.

[5] Despite missing the final due to injury,[6] Khamis helped Ahed lift the 2019 AFC Cup title.

[7] On 13 February 2020, Khamis joined Malaysia Super League side Pahang on a season-long loan from Ahed.

[10] On 6 January 2024, Khamis was called up to the Lebanon squad for the 2023 AFC Asian Cup, replacing George Felix Melki who withdrew injured before the competition.