Kham Thale So (Thai: ขามทะเลสอ, pronounced [kʰǎːm tʰā.lēː sɔ̌ː]; Northeastern Thai: ขามทะเลสอ, pronounced [kʰǎːm tʰā.lêː sɔ̌ː]) is a district (amphoe) of Nakhon Ratchasima province, northeastern Thailand.

Neighbouring districts are (from the north clockwise) Non Thai, Mueang Nakhon Ratchasima, Sung Noen, and Dan Khun Thot.

Kham Thale So is also a township (thesaban tambon) which covers parts of the tambon Kham Thale So.

The district is the site of salt mines operated by the Saltworks Company, a major producer of salt for the chemical and food industries.

[1] This Nakhon Ratchasima Province location article is a stub.