Khandwa Lok Sabha constituency is one of the 29 Lok Sabha constituencies in the Indian state of Madhya Pradesh.

This Khandwa constituency came into existence in 1957.

It covers the entire Burhanpur district and parts of Dewas, Khandwa and Khargone districts.

Presently, since the delimitation of the parliamentary and legislative assembly constituencies in 2008, Khandwa (खण्डवा) Lok Sabha constituency comprises the following eight Vidhan Sabha (Legislative Assembly) segments: ^ by-poll