The national park covers an area of 483 square kilometres (186 sq mi) and was established in 2012.

The national park is named after Khao Kho, a mesa high 1,143 metres (3,750 ft).

[5] This part of the Phetchabun mountain range is the origin of the main tributaries of the Pa Sak, Yom and Nan rivers.

[6] Weather measurement station at the Khao Kho National park collects data of temperature, relative humidity and rainfall since June 1999.

The park is generally cool all year round, with rainy season around mid-May to October.