Universal's Mummy films were inspired by worldwide interest in Egyptian archeology during the first half of the 20th century.

Although the iconic image of the mummy's face is usually Karloff's, the Kharis films are responsible for the enduring stereotype of the lumbering, foot-dragging monster, as Karloff's bandaged creation is seen only briefly, while Kharis is a major on-screen character in all four follow-up films.

Eddie Parker portrayed Klaris, a cousin of Kharis, in the 1955 comedy Abbott and Costello Meet the Mummy.

In Frank J. Dello Stritto's 2021 novel, The Passion of the Mummy, a boy on a class trip somehow makes mental contact with the still sentient Kharis.

The game retroactively establishes The Mummy films of the 1930s–1950s as part of the canonical chronology of the Dark Universe.