Khirbat Qais (Arabic: خربة قيس) is a Palestinian village in the Salfit Governorate in the northern West Bank.

[4] In the 18th and 19th centuries, the village formed part of the highland region known as Jūrat ‘Amra or Bilād Jammā‘īn.

Situated between Dayr Ghassāna in the south and the present Route 5 in the north, and between Majdal Yābā in the west and Jammā‘īn, Mardā and Kifl Ḥāris in the east, this area served, according to historian Roy Marom, "as a buffer zone between the political-economic-social units of the Jerusalem and the Nablus regions.

On the political level, it suffered from instability due to the migration of the Bedouin tribes and the constant competition among local clans for the right to collect taxes on behalf of the Ottoman authorities.

[7] In 1870/1871 (1288 AH), an Ottoman census listed the village with a population of 28 households in the nahiya (sub-district) of Jamma'in al-Awwal, subordinate to Nablus.