Khirbet al-Ma'zah (Arabic: خربة المعزة) is a town in western Syria, administratively part of the Tartus Governorate.

According to the Syria Central Bureau of Statistics (CBS), Khirbet al-Ma'zah had a population of 4,798 in the 2004 census.

It is the administrative center of the Khirbet al-Ma'zah Subdistrict (nahiyah) which consisted of 11 localities with a collective population of 22,897.

[1] The inhabitants of the town and the subdistrict are predominantly Alawites, mainly from the Kalbiyya tribal confederation.

[2] On December 26, 2024, former Syrian major general Mohammad Kanjo Hassan was found hiding in a hole in Khirbet al-Ma'zah, he was arrested along with 20 of his loyalists.