[1] In 1986, the area around Khoiniki experienced heavy radioactive fallout from the Chernobyl accident; however, the city itself was not significantly affected.

Today, the town hosts the headquarters of Polesie State Radioecological Reserve and employs over 700 people.

According to historical records, Khoiniki was first mentioned in 1504 as a dependency of the Grand Duchy of Lithuania.

In 1897, the city, located in the Pale of Settlement, had a large Jewish community of 1,668 people (62% of the total population).

[4] In 1919, Khoiniki was attached to the Russian Soviet Federative Socialist Republic.