Khok Si Suphan (Thai: โคกศรีสุพรรณ, pronounced [kʰôːk sǐː sù.pʰān], Northeastern Thai: โคกสีสุพรรณ, pronounced [kʰôːk sǐː su᷇.pʰân]) is a district (amphoe) of Sakon Nakhon province, northeast Thailand.

The minor district (king amphoe) was created on 5 May 1981, when the three tambons Tong Khop, Lao Phon Kho, and Dan Muang Kham were split off from Mueang Sakon Nakhon district.

The people of Khok Si Suphan are predominantly of Phu Thai and Nyaw ethnicity.

The district is divided into four sub-districts (tambons), which are further subdivided into 52 villages (mubans).

This Sakon Nakhon Province location article is a stub.