The film stars the voices of Jake T. Austin, Steve Buscemi, Loretta Devine, Laurence Fishburne, Richard E. Grant, AnnaSophia Robb, Anika Noni Rose, Catherine Tate, Ben Vereen, and Liam Neeson.

The film was dedicated in memory of The Quagga Breeding Project founder Reinhold Rau, who died on February 11, 2006.

Rau was known for efforts to use selective-breeding to recreate the extinct quagga, a close relative of the plains zebra.

Khumba aids a migrating herd of springbok in opening a hole in a great fence to continue journeying forward.

Khumba encounters a group of rock hyraxes who worship the Black Eagle and stymie his advance.

The Black Eagle also reveals that Phango murdered his clan as revenge for being rejected when he was a cub, due to him being born with one eye blind, which gave him a keener sense of smell to be a better hunter.

While Khumba wanders the depths of the dark cave, his herd arrives at the base of the mountain, along with many of the other animals he has encountered along his journey.

Within the cave, Khumba finds the watering hole and upon reflecting on Lungisa's words and all of the interactions he has had, he realizes that diversity is essential for survival that would be one's difference that can, in fact, be one's strength.

The assembled animals watch the fight between Khumba and Phango, which results in both of them falling due to the collapsing cave.

Songs for the soundtrack were all written by Retief are performed by various artists, including Loyiso Bala, Heavenly Quartez, the Karoo Children's Choir, and Richard E. Grant.