Nkhumeni "Khume" Ramulifho (born 27 February 1979) is a South African politician of Rise Mzansi, previously the Democratic Alliance where he served as Federal Youth Leader and a member of the Gauteng Provincial Legislature for the party.

From October 2011, he was the DA Gauteng South Chairperson, until joining Rise Mzansi in January 2024.

[4] In March 2018, Ramulifho announced his candidacy for Deputy Chairperson of the Federal Council.

[6][7] In October 2019, Ramulifho declared his candidacy for the post of interim Federal Chairperson of the Democratic Alliance after Athol Trollip resigned.

In January 2024, Ramulifho announced that he was leaving the DA to join Rise Mzansi.