As the North-West Frontier Province (NWFP), the team played its inaugural season in the Ranji Trophy in 1937.

A new Khyber Pakhtunkhwa team was introduced as a part of the new domestic structure announced by the Pakistan Cricket Board (PCB) on 31 August 2019.

Khyber Pakhtunkhwa finished in third and fourth place respectively in the Quaid-e-Azam Trophy and National T20 Cup.

The final against Central Punjab (Quaid-e-Azam Trophy) resulted in a tie, and they were declared joint winners.

Khyber Pakhtunkhwa won their second National T20 Cup by defeating Central Punjab in the final.