[1] The main line (186 miles) runs from Hope, Arkansas (where it interchanges with Union Pacific Railroad) to Lakeside, Oklahoma, then along 20 miles of BNSF Railway trackage rights to a BNSF interchange point at Madill, Oklahoma.

[1][5] KRR traffic generally consists of coal, lumber, paper, glass, cement, pulpwood, stone and food products.

As of 2023, Genesee & Wyoming's Kiamichi Railroad holds a total of 264 miles (36 in Arkansas, 199 in Oklahoma, and 30 in Texas), has a maximum capacity of 263,000 in Antlers Branch (286,000 elsewhere).

Tyson began construction on the new mill in June 2020, with Kiamichi investing roughly $9 million in improvements that support the increase of demand.

On May 10, 2022, the Kiamichi Railroad began a $65 million feed mill in McNab, Arkansas, as a multi-year project with Tyson Foods.