Founded in 1871, the hospital is run by the Kiang Wu Charitable Association and offered Chinese medical services.

Renowned doctor Sun Yat-Sen brought Western medicine services to the hospital.

The doctors were trained at universities in Mainland China and Taiwan, with about one-third each graduating from the School of Medicine at Jinan University and the Zhongshan School of Medicine.

The nurses earned certificates in nursing at schools in Mainland China, at Macao Polytechnic University (formerly Macao Polytechnic Institute), and at Kiang Wu itself.

It became a degree granting college (Bachelor of Science in Nursing) in 2002.