Kiatisuk Senamuang played with Perlis in Malaysia before joining an English club Huddersfield Town in 1999, which the then manager, Steve Bruce, considered merely a publicity stunt.

[3] After one season, in which he did not feature in the Huddersfield Town first team squad, Kiatisuk left English football for Rajpracha Sports Club in Thailand, later joining Singapore Armed Forces FC where he scored 15 goals in 20 games.

In March 2002, he moved once again to become a star in Vietnam with Hoàng Anh Gia Lai, where he helped win the V.League 1 title several times.

He led Hoàng Anh Gia Lai to the final of the 2010 Vietnamese Cup but lost 0–1 to Sông Lam Nghệ An at Thống Nhất Stadium, Ho Chi Minh City.

After ten games in the top league, Kiatisuk resigned from his position due to poor results: 1 win, 4 draws, and 5 losses.

[8] In June 2013, Kiatisuk was appointed as a caretaker head coach of Thailand senior team, replacing Winfried Schaefer.

His debut match as head coach of the War Elephants was in a friendly against China on 15 June 2013, which the Thais won 5–1.

[11] In 2014, due to his success in 2014 Asian Games, Kiatisuk was appointed to be a permanent head coach of Thailand to compete in the 2014 AFF Championship.

[12] In 2015, for the second round of 2018 FIFA World Cup qualification, Thailand was drawn in the same group as Iraq, Vietnam and Chinese Taipei.

[13] Nevertheless, Thailand managed to secure a return of the trophy with a 2–0 win at Rajamangala Stadium and lifted their fifth regional title on 17 December 2016.

Kiattisuk became the third manager, after Peter Withe and Radojko Avramović, to successfully defend the AFF Championship title.

Three days after a 0–4 loss to Japan at Saitama Stadium 2002 on 28 March 2017, Kiatisuk stepped down from his position as the manager of the national team after four years in charge.

[16] On 20 November 2020, Kiatisuk was appointed head coach with a two-year contract of Hoàng Anh Gia Lai, his former Vietnamese club.