The Kidepo Game Reserve is a protected area located in Ikotos and Budi counties, Eastern Equatoria State, South Sudan, Africa.

With an area of 1200 km2,[1] this reserve is located 4° 04'N and 33° 28'E on the South Sudan/Uganda border, where it forms a contiguous ecosystem with Uganda's Kidepo Valley National Park.

Three quarters of the Kidepo Game Reserve is in Bira Payam of Ikotos County and also part of Budi County, which is inhabited by the Ketebo, Didinga and Buya and the word "Kidepo" come from the Ketebo word "Kidebo", which mean "Help us".

The 1,200 square kilometres (460 sq mi) reserve includes savanna, grassland, and woodland habitats.

It is likely that due to the protracted war and many other conservation challenges listed below the numbers of wildlife have been reduced in a similar way as those in Nimule and Southern national parks.