Kiki Sukezane was born to parents both of Samurai descent, into a local family noted for its ancestry, whose surname can be traced back to swordsmiths from the 13th century; some ancestors were involved in the 1860 Sakuradamon Incident on the side of the Rōnin, and others were Ochimusha under the Taira clan.

[1][2][3][4] Her paternal uncle, Tomoki Sukezane (Japanese: 祐真朋樹), is a noted stylist and fashion magazine editor.

[5] Sukezane spent a year in the United States as a foreign exchange student in South Dakota and learned English.

[6] In her first major break she played Miko Otomo/Katana Girl in NBC's Heroes Reborn miniseries from 2015 to 2016.

[7][8] She followed it up with roles in Netflix's Lost in Space and Earthquake Bird, HBO's Westworld and more recently AMC's The Terror: Infamy.