Both hurling and Gaelic football are played in the "North-Tipperary" divisional competitions.

The club was founded in 1937 and is named after Thomas MacDonagh, a signatory of the 1916 Proclamation who was born and lived in Cloughjordan.

The finest day in the club's history was in 1986 when it won the Senior Hurling Club All-Ireland title, defeating Buffers Alley of Wexford GAA in the final by 1-15 to 2-10.

A forerunner to the MacDonaghs club was the famous De Wets formed in 1900.

On 30 October 2022, Kilruane MacDonaghs defeated Kiladangan 2-20 to 1-16 in the 2022 Tipperary Senior Hurling Championship final after a replay to win their first title since 1985.