In late 2001, Kim Medcalf took over the role of Sam Mitchell from Danniella Westbrook who was recovering from addiction at the time.

Her character escaped imprisonment as an accessory to the murder of Den Watts (Leslie Grantham) and departed Walford to join her brother, Grant Mitchell (Ross Kemp), in Brazil.

[11][12] In Spring 2006, she undertook a four-month run in the revival of Hay Fever at the Theatre Royal Haymarket alongside Judi Dench.

[15] In February and March 2007, Medcalf appeared as the "guest star" in a short UK tour of the West End hit The Play What I Wrote.

[16] On 2 April 2007, Medcalf took over the role of Sally Bowles from Anna Maxwell Martin in Rufus Norris' revival of Cabaret at the Lyric Theatre in the West End.

[17] From 25 February until 1 March 2008, Medcalf appeared in a run of The Vagina Monologues at the New Victoria Theatre, Woking, alongside Sue Holderness and Shobna Gulati.

[17] In early 2009, she returned to The Vagina Monologues, this time in Nottingham,[18] Medcalf appeared in two episodes of BBC One drama Missing in 2010.