She was the lead vocalist, guitarist, and primary songwriter of the American punk rock band the Muffs, which formed in 1991.

In 2001, she was a singer, guitarist and songwriter for The Beards, a side project composed of Shattuck, Lisa Marr, and Sherri Solinger.

In 1991, switching to guitar and assuming lead vocals, she formed the Muffs in Los Angeles with fellow Pandoras veteran Melanie Vammen.

[8] Shortly before her death, she recorded a six-song EP with Vammen and Palmyra Delran as The Coolies, which included a special appearance by Stevie Van Zandt on theremin.

Shattuck died at her home in Los Angeles on October 2, 2019, from complications of amyotrophic lateral sclerosis, aged 56.