She was the Republican nominee for Maryland's 2nd congressional district in the 2024 general election, in which she was defeated by Baltimore County Executive Johnny Olszewski.

[13] Fox News in 2019 called her a "Republican strategist" and noted her critiques of Congressman Elijah Cummings and the living standards and safety issues in his district.

[14] In a July 2019 interview on Fox & Friends, Klacik talked about Cummings's Baltimore district being overrun by trash and dilapidation.

An hour later, President Donald Trump echoed the segment by beginning to disparage both the city of Baltimore and Cummings on Twitter in a series of 19 tweets over two days.

[23][24] On August 18, 2020, Klacik's campaign released a viral video, titled "Black Lives Don't Matter To Democrats", which was filmed in a dilapidated area of Baltimore.

[27][26] Klacik also criticized the Democratic leaders of Maryland's 7th congressional district, citing Baltimore's alleged notoriety as being among the most dangerous cities in America.

The video was conceived of and directed and produced by Benny Johnson, chief creative officer of Turning Point USA.

One of them, Arsenal Media Group, who had contracted with Benny Johnson to script and direct the August 2020 campaign video, received over $500,000.

Klacik's campaign initially reported part of it to the Federal Election Commission as payments to Republican fundraising platform WinRed.

[45][46] On February 8, 2024, Klacik announced that she would run for Congress in Maryland's 2nd congressional district, seeking to succeed retiring U.S. Representative Dutch Ruppersberger.

[53] Commentator Candace Owens accused Klacik of being a strip club “madame” who spent campaign funds on cocaine.