It leaves the main King's Cross gyratory near the Clink78 hostel, signposted towards the City of London.

The A201 enters the City of London at a junction with Charterhouse Street (which leads to Holborn Circus, the A4, and the A40).

At St George's Circus, southbound traffic may continue towards Elephant and Castle along London Road.

The route ends at Bricklayer's Arms at a junction with the A100/Tower Bridge Road and the A2/Great Dover Street.

Southbound cyclists cross Farringdon Road to the south of the Holborn Viaduct, where the route continues as a two-way bike freeway towards Blackfriars Bridge.