[1] The hound was passed to the king's daughter, Anne de Beaujeu, he was widely used at stud and his white progeny gradually replaced the hounds in the king's pack until the whole pack was white.

[1][2] Several notable infusions of outside blood were added to the pack, in 1500 Louis XII introduced an Italian Pointer called Greffier, in 1520 François I introduced a powerful Grand Fauve de Bretagne called Miraud, and in 1560 Mary, Queen of Scots gifted a Talbot Hound named Barraud to her husband François II, all of these infusions improved the breed.

[1][2] The White Hounds reached the height of their fame during the reign of Louis XIII (1610–1643) when they were renowned throughout Europe for their speed, being able to run a stag down in half an hour and kill four stags in a day's hunting.

[3] By this time the breed displayed many sighthound features and hunted as much by sight as by scent.

[1][3] The King's White Hounds are believed to have been foundational in the development of a number of French hound breeds, including the Grand Griffon Vendéen, the Porcelaine and the Billy, the latter is sometimes called the Chien Blanc du Roi.